Abstract Purpose High-dose methotrexate (HDMTX) is administered for the treatment of a variety of malignant tumors. Wide intra- and inter-individual variabilities characterize the pharmacokinetics of
Archives: Publications
ABSTRACT: There is a significant hype in the medical sector for the transdermal administration of drugs as it allows achieving a combination of multiple advantages:
ABSTRACT: This work proposes an application of a minimal complexity physiologically based pharmacokinetic model to predict tramadol concentration vs time profiles in horses. Tramadol is
Pharmacokinetic modeling based on a mechanistic approach is a promising tool for drug concentrationprediction in living beings. The development of a reduced physiologically-based pharmacokinetic model(PBPK
Pharmacokinetic modeling allows predicting the drug concentration reached in the blood as a consequence of a specific administration. When such models are based on mammalian
Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a given administration. Models based on body anatomy and physiology can
This paper focuses on a physiologically-oriented mathematical model aimed at studying the in vivo drug release, absorption, distribution, metabolism and elimination (ADME). To this purpose,
The paper focuses on crude oil refineries and presents a methodology to determine dynamic models of prices of different oils and the derived distillates. It
In this work, a reverse osmosis (RO) desalination process operating under batch mode is considered experimentally. The effect of operating parameters, such as pressure and
Automation in the process industry has seen its implication and implementation since 1960’s. However, during last decades the “trend” of integrating advanced and sophisticated process
The increasing complexity of chemical processes, in terms of technological involvement, intensified with automation, has made the role and job of industrial operators more significant
The paper discusses the specifications and features of an automated assessment procedure for training of industrial operators. A case study applied to a real catalyst‑injector‑switch
Managing complex systems is a challenging task as decisions are much more difficult to make and consequences (in case of wrong decision) much harder to
The Viareggio railway accident took place in the night of June 29th, 2009, with the derailment of a freight train, the emission and dispersion of
The water permeability constant, Kw, is one of the many important parameters that affect optimal design and operation of RO processes. In model based studies,