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Archives: Publications

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Home News Publications

GHG Emissions by (Petro)Chemical Processes and Decarbonization Priorities—A Review

AUTHORS: Andrea Isella, Davide Manca ABSTRACT: Global warming is becoming an increasing issue, and greenhouse gas (GHG) emissions represent the engine of such a phenomenon. This

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A minimal physiologically based pharmacokinetic model for high‑dose methotrexate

Abstract Purpose High-dose methotrexate (HDMTX) is administered for the treatment of a variety of malignant tumors. Wide intra- and inter-individual variabilities characterize the pharmacokinetics of

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Home News Publications

A physiologically-based diffusion-compartment model for transdermal administration – The melatonin case study

ABSTRACT: There is a significant hype in the medical sector for the transdermal administration of drugs as it allows achieving a combination of multiple advantages:

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A physiologically based model for tramadol pharmacokinetics in horses

ABSTRACT: This work proposes an application of a minimal complexity physiologically based pharmacokinetic model to predict tramadol concentration vs time profiles in horses. Tramadol is

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Definition and validation of a patient-individualized physiologically-based pharmacokinetic model

Pharmacokinetic modeling based on a mechanistic approach is a promising tool for drug concentrationprediction in living beings. The development of a reduced physiologically-based pharmacokinetic model(PBPK

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A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling

Pharmacokinetic modeling allows predicting the drug concentration reached in the blood as a consequence of a specific administration. When such models are based on mammalian

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Sorafenib in Mice – A Pharmacokinetic Study

Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a given administration. Models based on body anatomy and physiology can

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A physiologically-oriented mathematical model for the description of in vivo drug release and absorption

This paper focuses on a physiologically-oriented mathematical model aimed at studying the in vivo drug release, absorption, distribution, metabolism and elimination (ADME). To this purpose,

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Publications

Stochastic Price/Cost Models for Supply Chain Management of Refineries

The paper focuses on crude oil refineries and presents a methodology to determine dynamic models of prices of different oils and the derived distillates. It

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Publications

Operation and Modeling of RO Desalination Process in Batch Mode

In this work, a reverse osmosis (RO) desalination process operating under batch mode is considered experimentally. The effect of operating parameters, such as pressure and

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Publications

Automation in process industry: Cure or curse? How can training improve operator’s performance

Automation in the process industry has seen its implication and implementation since 1960’s. However, during last decades the “trend” of integrating advanced and sophisticated process

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How Distributed Situation Awareness Influences Process Safety

The increasing complexity of chemical processes, in terms of technological involvement, intensified with automation, has made the role and job of industrial operators more significant

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Procedure for Automated Assessment of Industrial Operators

The paper discusses the specifications and features of an automated assessment procedure for training of industrial operators. A case study applied to a real catalyst‑injector‑switch

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Experiment-Based Decision Making in Complex Systems

Managing complex systems is a challenging task as decisions are much more difficult to make and consequences (in case of wrong decision) much harder to

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New Insights into the Viareggio Railway Accident

The Viareggio railway accident took place in the night of June 29th, 2009, with the derailment of a freight train, the emission and dispersion of

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