A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling


Congress A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling

Authors: Roberto Andrea Abbiati, Gaetano Lamberti, Anna Angela Barba, Mario Grassi, Davide Manca

Computer Aided Chemical Engineering, 37, 77-84, 2015

http://www.sciencedirect.com/science/article/pii/B9780444635785500104

Go to DOI : 10.1016/B978-0-444-63578-5.50010-4

Pharmacokinetic modeling allows predicting the drug concentration reached in the blood as a consequence of a specific administration. When such models are based on mammalian anatomy and physiology it is possible to theoretically evaluate the drug concentration in every organ and tissue of the body. This is the case of the so-called physiologically based pharmacokinetic (PBPK) models. This paper proposes and validates a procedure to deploy PBPK models based on a simplified, although highly consistent with human anatomy and physiology, approach. The article aims at reducing the pharmacokinetic variations among subjects due to inter-individual variability, by applying a strategy to individualize some model parameters. The simulation results are validated respect to experimental data on remifentanil.