PSE-Lab published a new paper!


PSE-Lab published a new paper!

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A joint collaboration between Ospedale San Paolo di Milano and the PSE-Lab published a new article on Computers and Chemical Engineering.

Till May 11, 2018 you can download a free copy of the article at the following link. Alternatively, the PSE-Lab version is always available.

 

A physiologically-based diffusion-compartment model for transdermal

administration – The melatonin case study

Adriana Savoca, Giovanni Mistraletti, Davide Manca

 

DOI: https://doi.org/10.1016/j.compchemeng.2018.03.008

 

Abstract

There is a significant hype in the medical sector for the transdermal administration of drugs as it allows achieving a combination of multiple advantages: non-invasive procedure, pain avoidance, no first-pass hepatic metabolism, and induction of sustained plasma levels. This paper proposes a model for the study and prediction of drug transport through skin and the following distribution to human body. This is achieved by an innovative combination of the physiologically-based compartmental approach with Fick’s laws of diffusion. The skin model features three strata: stratum corneum, viable epidermis, and dermis, which have a major impact on the absorption, distribution, and metabolism of transdermal drugs. The combined model accounts for skin transport via diffusion equations, and absorption and distribution in the rest of the body (i.e. organs/tissues) via material balances on homogeneous compartments. Experimental data of transdermal melatonin allow validation. Main applications are optimization of the dosage and study of skin transport.

 

Keywords

Transdermal delivery
Pharmacokinetic simulation
Model sensitivity
Administration route
ADME
Melatonin
Skin diffusion