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A physiological control system for anesthesia delivery   Application of automated control devices in biomedicine is still emergent, but very promising. Currently, anesthesiologists set an initial dose of analgesic/anesthetic for surgical interventions according to their experience and standard protocols, and then make adjustments after patients’ observation. This approach to anesthesia can lead to intermittent and irregular...

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A joint collaboration between Ospedale San Paolo di Milano and PSE-Lab carried to the publication of a new article on Computers and Chemical Engineering. The interested readers can download the PSE-Lab version.   A physiologically-based diffusion-compartment model for transdermal administration – The melatonin case study Adriana Savoca, Giovanni Mistraletti, Davide Manca  ...

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Juan Pablo Gutierrez is a Chemical Engineer and PhD in Engineering. Coming from Argentina, Juan joined the PSE-Lab in September 2017, promoted by the ERASMUS Sustaint-T Program of the European Commission. Aim of his stay is to evaluate the potential of CO2 Enhanced Oil Recovery (CO2 EOR) to be implemented in his home country. His analysis takes into consideration the three pillars of the sustainability. His research background...

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A joint collaboration between the Veterinary department of the University of Milan and the PSE-Lab published a new article on Journal of Theoretical Biology. Till August 17, 2017 you can download a free copy of the article at the following link. The universal link is: http://dx.doi.org/10.1016/j.jtbi.2017.06.028   A physiologically based model for tramadol pharmacokinetics in horses Roberto Andrea Abbiati, Petra Cagnardi,...

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  PSE-Lab published a new article on Industrial and Engineering Chemistry Research:   Enterohepatic Circulation Effect in Physiologically Based Pharmacokinetic Models: The Sorafenib Case Roberto Andrea Abbiati, Davide Manca   Abstract Sorafenib was recently approved by both FDA and EMA for the treatment of unresectable hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), and thyroid cancer (DTC). This paper...

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  PSE-Lab organized a seminar which is scheduled for Wednesday, February 22, 2017 at 2:30 PM at Politecnico di Milano, Aula Natta, CMIC Department, Building 6. Quantitative Systems Pharmacology: Application to translational research and personalized/precision medicine prof. Jessie Au Founding Director of the Institute of Quantitative Systems Pharmacology e Research Professor & Mosier Endowed Chair in Pharmaceutical Sciences,...

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Oh yes, we love Latin: CUM LAUDE! On December 21th, 2016, Piernico Sepiacci defended his master degree thesis on “Conceptual Design of Chemical Plants by Multi-Objective Optimization of Economic and Environmental Criteria” and received the maximum mark of 110/110 cum laude. He worked hard at PSE-Lab and could materialize his achievements in terms of an outstanding thesis that took also to the very recent publication of a...

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