Membro staff

Adriana Savoca

Adriana Savoca began to work at PSE-Lab in 2015 during the Master in Chemical Engineering at Politecnico di Milano and graduated with the thesis “A pharmacokinetic-pharmacodynamic model for remifentanil administration in anesthesia“, developed under the supervision of Prof. Davide Manca. The main drivers of the activity were physiologically-based pharmacokinetic and pharmacodynamic simulations with focus on the individualization of the prediction.

She started her work as PhD student in November 2016, with focus on control of anesthesia delivery and optimization of drug administration.

Beside the research activity, Adriana is also a tutor for the labs of:

- “Strumentazione e Controllo degli Impianti Chimici“ (Bachelor course)

- “Process Systems Engineering” (Master course)

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Giuseppe Pesenti

Giuseppe Pesenti is a PhD student and joined the PSE-Lab in November 2017.

He graduated from Politecnico di Milano with a Master Degree in Chemical Engineering in 2016, with the thesis ”Pharmacokinetic and pharmacodynamic model for the oral administration of antihistamines” developed at the PSE-Lab under the supervision of prof. Davide Manca.

His work is focused on physiologically-based pharmacokinetic and pharmacodynamic models. He is currently working on the development of pharmacokinetic models for antitumoral and antibiotic drugs.

He is also responsible for the tutoring of the Bachelor Course ”Strumentazione e Controllo degli Impianti Chimici” at Politecnico di Milano.

Roberto Andrea Abbiati

Roberto Andrea Abbiati joined PSE-Lab in 2013, after the Master graduation in Chemical Engineering at Politecnico di Milano. As a PhD student his focus is on pharmaceutical research, specifically in pharmacokinetic/pharmacodynamic modeling to describe the behavior of new anti-cancer drugs in the human body.

The project is developed under the supervision of prof. Davide Manca in collaboration with a wide group of Italian universities and is funded by the Italian government.

The main research interest is in:

Beside the research activity, Roberto is also responsible for the labs of the courses Strumentazione e Controllo degli Impianti Chimici“ for bachelor students and “Process Systems Engineering” for master students, given for the degree in Chemical Engineering at the Politecnico di Milano.

Salman Nazir

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Salman Nazir has joined PSE-Lab since 2011. He is currently a research fellow (postdoc) in PSE-Lab. He has been focused on improvement in Industrial Safety by deploying constructs from Human Factors research since last four years. He has received his Masters in Chemical Engineering with focus on Process System Engineering, from Hanyang University, South Korea.

He has successfully finished his PhD (with cum laude) under the supervision of prof. Davide Manca (head of PSE-Lab).

Following are the topics which defines the research focus of Dr. Nazir:

Human Factors
Situation Awareness (SA)
Distributed Situation Awareness (DSA)
Performance Assessment and Analysis
Abnormal Situation Management
Key Performance Indicators (KPIs)
Operator performance indicators (OPIs)
KPIs and OPIs for measurement of SA and DSA
Training Methods
Performance Management
Performance Evaluation/Assessment
Design of Experiment
Impact of Training Methods on Performance
Operator Training Simulator
Virtual and Augmented Virtual Environments
Analytic Hierarchy Approach (AHP)
Industrial Accidents and their Mitigation
COCOM and CREAM models
Immersive Environment
Spatial Learning
Statistical Methods

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Davide Manca

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Research fields


Design and Simulation
Design of process units and chemical equipment
Conceptual design of chemical/industrial processes
Dynamic conceptual design for economic uncertainties, market fluctuations, demand/offer variability
Feasibility studies under price/cost uncertainty of OPEX terms

Process control and Optimization
Dynamic simulation of chemical processes
Conventional process control based on feedback loops
Model identification, soft sensors
Model based control – Model Predictive Control
Data reconciliation and coaptation
On-line optimization and supervision of chemical plants

Process safety
Dynamic modeling of accidents (industrial, transportation, civil) and event reconstruction
Liquid/Gas emissions, pool spreading, ignition, pool fire, jet fire, flash fire, fireball,
thermal radiation, thermal load, equipment resistance, gas (buoyant and dense) dispersion
Detonation of solid explosives, blast, overpressure, impulse, radiation, seismic wave
Design for maximum explosive load of warehouses/depots according to safety thresholds
Top events identification and quantification
Safety Reports (EC Seveso Directives)
Operator training simulation
Real-time performance assessment of field and control-room operators

Pharma processes
Microencapsulation of active principles
Release of drugs in the human body
Pharmacokinetic modeling based on compartment models with anatomy/physiology contributes
Process Analytical Technologies (PAT) and Quality by design (QbD)
Design of batch and continuous equipment in the pharma industry
Granulators, driers, perforated pans
Process monitoring of the assigned recipe
Optimal trajectory of process setpoints for on-, in-line control
Real-time photographic techniques for not intrusive control of process variables and end-point identification


International Research Cooperations

Prof. J.A. Fay – MIT, USA, “Pool spreading and evaporation”
PhD. S. Hanna – Hanna Consulting, USA, “Pool spreading and evaporation”
Prof. D.M Webber – HSE, UK, “Pool spreading and evaporation”
Prof. P.W.M. Brighton – HSE, UK, “Pool spreading and evaporation”
PhDs M. Brown, Reisner, Chang – LANL, USA, “Dispersion of heavy and buoyant gases in complex industrial environments”
Prof. P. A. Webley , Monash University – Australia, “Numerical solution of stiff ODE systems”
Prof. U. Diwekar – Vishwamitra Research Institute, USA, “Multiobjective optimization of fuel-cell systems for trucks”
Prof. V. Plesu – Bucarest, Romania – Reviewer of the Ph.D. thesis of Petrica Iancu “Process integration for water minimization in oil processing and petrochemistry”
Prof. R. Aguilar-López – Special issue of Chemical Product and Process Engineering “Process modeling and Control”, Departamento de Biotecnología y Bioingeniería, CINVESTAV-IPN – Mexico
Prof. I. Mujtaba – Bradford University, UK – Research activity on Water Desalination Systems
Prof. IL Moon – Yonsei University, Korea – Price forecast of commodities and utilities
Prof. Fengqi You – Northwestern University, USA – Supply chain management
Prof. Annette Kluge – Duisburg University, Germany – Human factors in industrial operators training
Prof. Kjell Ivar Øvergård – Buskerud and Vestfold University College, Norway – Human Factors in the maritime sector


European Community Projects

Virthualis: VIrtual RealiTy and HUman Factors AppLications for Improving Safety
Pre-Emergencies: an EC DG Environment cofinanced project


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Campi di Ricerca e Attività scientifica

Progettazione di operazioni unitarie e di impianti
Simulazione ed identificazione di processo. Reti neurali
Modellazione dettagliata di processi chimici

Dinamica dei processi e Controllo basato su modello. Model Predictive Control.
Ottimizzazione e Supervisione di processi chimici. Tecniche convenzionali ed Algoritmi genetici
Supply Chain Management

Impianti di Termovalorizzazione
Diagnostica termografica di cavità radianti

Microincapsulazione di farmaci
Attivazione meccanochimica di principi primi ad alta energia
Ottimizzazione della progettazione e dello scheduling di processi discontinui
PAT – Process Analytical Technologies per il settore farmaceutico, chimica fine ed alimentare

Rischio chimico-industriale, Direttiva Seveso II e III, Elaborato di Rischio di Incidente Rilevante, Rapporti di Sicurezza
Programmazione e gestione dell’emergenza
Modellazione delle emissioni e ricadute al suolo di specie micro e macroinquinanti
Emissioni di gas a effetto serra ai sensi direttiva 2003/87/CE

Calcolo numerico, sistemi AE, ODE, DAE, Ottimizzazione MILP e MINLP

Formazione Universitaria

Laurea in ingegneria Chimica
Dottorato di Ricerca in Ingegneria Chimica

Carriera Accademica

Ricercatore I15D (attuale ING-IND/26) nel 1995
Ricercatore Confermato I15D (attuale ING-IND/26) nel 1998
Professore Associato ING-IND/26 nel 2002
Professore Associato Confermato ING-IND/26 dal 2005

Attività Didattiche e di Formazione

Laurea di primo livello: Calcoli di Processo dell’Ingegneria Chimica; Strumentazione e Controllo degli Impianti Chimici
Laurea Specialistica: Process Systems Engineering; Progettazione di Processo e Analisi dei Costi; Sicurezza della Città e del Territorio
Laurea Vecchio Ordinamento: Teoria dello Sviluppo dei Processi Chimici II
Dottorato di ricerca: Metodi avanzati per la progettazione ed ottimizzazione di processo

Docente Fisica Tecnica per corsi SILSIS
Docente scuole di dottorato: ADP, AMO, CIP, MEMIC
Docente corsi di Formazione Permanente e Master: POLIMI, AIRU, IREF
Tutor di attività di tirocinio per laurea di primo livello
Relatore di tesi di laurea per laurea di secondo livello


Cariche Ricoperte

Commissione Relazioni Esterne
Commissione Permanente Consiglio Corso di Studi in Ingegneria Chimica
Commissione Informatica di Dipartimento
Giunta di Dipartimento
Commissione Pubblicazioni di Dipartimento
Commissione Ristrutturazione sede Leonardo


Progetti Europei

Virthualis: VIrtual RealiTy and HUman Factors AppLications for Improving Safety
Pre-Emergencies: an EC DG Environment cofinanced project